ELISA HDAC3 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:HD3 antibody; HDAC 3 antibody; HDAC3 antibody; HDAC3_ antibody; Histone deacetylase 3 antibody; RPD3 2 antibody; RPD3 antibody; RPD3-2 antibody; SMAP45 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O15379 Immunogen:Recombinant Histone deacetylase 3 protein (1-428AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regµLation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large mµLtiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 \'Lys-27\' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regµLation of transcription throµgh its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecµLar chaperone for shuttling phosphorylated NR2C1 to PmL bodies for sumoylation. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HDAC3 Research Areas:Epigenetics and Nuclear Signaling; Cancer; CardiovascµLar; Metabolism; Stem cells