ELISA HDAC9 anti-

Quantity :100µL Clone Number: Aliases:HD 7 antibody; HD 7B antibody; HD 9 antibody; HD7 antibody; HD7B antibody; HD9 antibody; HDAC 7 antibody; HDAC 7B antibody; HDAC 9 antibody; HDAC 9B antibody; HDAC 9FL antibody; HDAC antibody; HDAC7 antibody; HDAC7B antibody; HDAC9 antibody; HDAC9_ antibody; HDAC9B antibody; HDAC9FL antibody; HDRP antibody; Histone deacetylase 4/5 related protein antibody; Histone deacetylase 7 antibody; Histone deacetylase 7B antibody; Histone deacetylase 9 antibody; Histone deacetylase 9A antibody; Histone deacetylase related protein antibody; Histone deacetylase-related protein antibody; KIAA0744 antibody; MEF2 interacting transcription repressor MITR antibody; MEF2 interacting transcription repressor protein antibody; MEF2-interacting transcription repressor MITR antibody; MITR antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9UKV0 Immunogen:A synthetic peptide of HDAC9 Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; WB:1:500-1:2000, IHC:1:50-1:200 Background:In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is a critical component of transcriptional regµLation and the acetylation of nucleosomal histones is a major source of this remodeling. Acetylation of lysine residues in the amino terminal tail domain of histone resµLts in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1–9. HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9. HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription. HDAC9 and HDAC9a are expressed in brain, skeletal muscle, kidney, placenta and pancreas. Clonality:Polyclonal Isotype:IgG Purification Method:Affinity purification Conjµgate:Non-conjµgated Buffer:Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HDAC9 Research Areas:Epigenetics and Nuclear Signaling;CardiovascµLar