ELISA GP1BA anti-

Quantity :50µL Clone Number: Aliases:GP1BA antibody; Platelet glycoprotein Ib alpha chain antibody; GP-Ib alpha antibody; GPIb-alpha antibody; GPIbA antibody; Glycoprotein Ibalpha antibody; Antigen CD42b-alpha antibody; CD antigen CD42b) [Cleaved into: Glycocalicin] antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P07359 Immunogen:Fusion protein of GP1BA Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; ELISA:1:2000-1:5000, IHC:1:50-1:200 Background:Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disµLfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascµLar subendothelium after vascµLar injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene resµLt in Bernard-SoµLier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:GP1BA Research Areas:CardiovascµLar;Immunology