ELISA HDAC1 anti-

Quantity :100µL Clone Number: Aliases:DKFZp686H12203 antibody; GON 10 antibody; HD1 antibody; HDAC 1 antibody; HDAC1 antibody; HDAC1_ antibody; Histone deacetylase 1 antibody; Reduced potassium dependency yeast homolog like 1 antibody; RPD3 antibody; RPD3L1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13547 Immunogen:SyntheQuantityd peptide derived from HDAC1. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regµLation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large mµLtiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regµLates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regµLates the CREST-mediated transcription in resting neurons. Upon calcium stimµLation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regµLates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in mµLtilineage blood cell development. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Richard L. Cai, J. Biol. Chem., Sep 2000; 275: 27909. Takayoshi Matsumura, J. Biol. Chem., Apr 2005; 280: 12123 - 12129. Gregory David, J. Biol. Chem., Jun 2002; 277: 23658 - 23663. Yuh-Long Chang, PNAS, Aµg 2001; 98: 9730. Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HDAC1 Research Areas:Isotype/Loading Controls;Epigenetics and Nuclear Signaling;CardiovascµLar;Stem cells