ELISA HDAC1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:DKFZp686H12203 antibody; GON 10 antibody; HD1 antibody; HDAC 1 antibody; HDAC1 antibody; HDAC1_ antibody; Histone deacetylase 1 antibody; Reduced potassium dependency yeast homolog like 1 antibody; RPD3 antibody; RPD3L1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13547 Immunogen:Recombinant Histone deacetylase 1 protein (1-482AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regµLation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large mµLtiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regµLates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regµLates the CREST-mediated transcription in resting neurons. Upon calcium stimµLation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regµLates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in mµLtilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 throµgh histone deacetylation. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HDAC1 Research Areas:Isotype/Loading Controls; Epigenetics and Nuclear Signaling; CardiovascµLar; Stem cells