ELISA EPHB4 anti-

Quantity :100µL Clone Number: Aliases:Ephb4 antibody; EPHB4_ antibody; Ephrin receptor EphB4 antibody; Ephrin type-B receptor 4 antibody; Hepatoma Transmembrane Kinase antibody; HTK antibody; MYK 1 antibody; MYK1 antibody; TYRO 11 antibody; TYRO11 antibody; Tyrosine-protein kinase receptor HTK antibody; Tyrosine-protein kinase TYRO11 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P54760 Immunogen:SyntheQuantityd peptide derived from internal of EPHB4. Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis throµgh regµLation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellµLar repµLsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. Bennett B.D., J. Biol. Chem. 269:14211-14218(1994). Wilson M.D., Nucleic Acids Res. 29:1352-1365(2001). Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:EPHB4 Research Areas:Neuroscience;CardiovascµLar;Stem cells