ELISA DLX5 anti-

Quantity :100µL Clone Number: Aliases:DLX5Homeobox protein DLX-5 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P56178 Immunogen:SyntheQuantityd peptide derived from internal of DLX5. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. StimµLates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. StimµLates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regµLating MYC promoter activity. Involved as a positive regµLator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. Ota T., Nat. Genet. 36:40-45(2004). Hillier L.W., Nature 424:157-164(2003). Willis D.M., J. Biol. Chem. 277:37280-37291(2002). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DLX5 Research Areas:Epigenetics and Nuclear Signaling?Neuroscience;Signal transduction?Stem cells