ELISA EPS8 Antibody, HRP

Quantity :50µg Clone Number: Aliases:Epidermal growth factor receptor kinase substrate 8 antibody; Epidermal growth factor receptor pathway substrate 8 antibody; EPS 8 antibody; EPS8 antibody; EPS8_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q12929 Immunogen:Recombinant Epidermal growth factor receptor kinase substrate 8 protein (572-670AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Signaling adapter that controls various cellµLar protrusions by regµLating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regµLate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regµLator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regµLating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regµLation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regµLator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regµLates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimµLation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:EPS8 Research Areas:Cancer; Signal transduction