ELISA HACE1 anti-

Quantity :50µg Clone Number: Aliases:HACE1 antibody; KIAA1320E3 ubiquitin-protein ligase HACE1 antibody; EC 2.3.2.26 antibody; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1 antibody; HECT-type E3 ubiquitin transferase HACE1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8IYU2 Immunogen:Recombinant E3 ubiquitin-protein ligase HACE1 protein (333-442AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:500-1:1000 Background:E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regµLation of small GTPases. Acts as a regµLator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regµLates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regµLator via its interaction with RARB. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HACE1 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cell biology