ELISA DKC1 anti-

Quantity :100µL Clone Number: Aliases:CBF5 antibody; CBF5 homolog antibody; Cbf5p homolog antibody; DKC 1 antibody; DKC antibody; Dkc1 antibody; DKC1_ antibody; DKCX antibody; Dyskeratosis congenita 1 antibody; Dyskeratosis congenita 1 dyskerin antibody; Dyskerin antibody; H/ACA ribonucleoprotein complex subunit 4 antibody; NAP 57 antibody; NAP57 antibody; NOLA 4 antibody; NOLA4 antibody; Nopp140 associated protein of 57 kDa antibody; Nopp140-associated protein of 57 kDa antibody; Nucleolar protein family A member 4 antibody; Nucleolar protein NAP57 antibody; snoRNP protein DKC1 antibody; XAP 101 antibody; XAP101 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O60832 Immunogen:SyntheQuantityd peptide derived from Internal of Dyskerin. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IF; WB:1:500-1:3000, IF:1:100-1:500 Background:Isoform 1:Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.Isoform 3:Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression (when overexpressed in HeLa cells). Heiss N.S., Nat. Genet. 19:32-38(1998). Knight S.W., Am. J. Hum. Genet. 65:50-58(1999). Hassock S., Genomics 55:21-27(1999). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DKC1 Research Areas:Epigenetics and Nuclear Signaling