ELISA EYA3 anti-

Quantity :50µL Clone Number: Aliases:AI844637 antibody; DKFZp686C132 antibody; EYA3 antibody; EYA3_ antibody; Eyes absent 3 antibody; Eyes absent 3 homolog (Drosophila) antibody; Eyes absent homolog 3 antibody; OTTMUSP00000010370 antibody; RP11-460I13.4 antibody; RP23-442A20.1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q99504 Immunogen:Recombinant Eyes absent homolog 3 protein (1-300AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 Background:Tyrosine phosphatase that specifically dephosphorylates \\\'Tyr-142\\\' of histone H2AX (H2AXY142ph). \\\'Tyr-142\\\' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regµLation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation throµgh recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:EYA3 Research Areas:Epigenetics and Nuclear Signaling; Signal transduction; Stem cells