ELISA HDAC3 anti-

Quantity :100µL Clone Number: Aliases:HD3 antibody; HDAC 3 antibody; HDAC3 antibody; HDAC3_ antibody; Histone deacetylase 3 antibody; RPD3 2 antibody; RPD3 antibody; RPD3-2 antibody; SMAP45 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O15379 Immunogen:SyntheQuantityd peptide derived from C-terminal of HDAC3. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 Background:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regµLation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large mµLtiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regµLation of transcription throµgh its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecµLar chaperone for shuttling phosphorylated NR2C1 to PmL bodies for sumoylation. Xiaohong Zhang, Genes & Dev., Apr 2005; 19: 827 - 839. Zhanguo Gao, J. Biol. Chem., Feb 2006; 281: 4540 - 4547. Andrew J. Wilson, J. Biol. Chem., May 2006; 281: 13548 - 13558. Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HDAC3 Research Areas:Epigenetics and Nuclear Signaling;Cancer?CardiovascµLar;Metabolism;Stem cells