ELISA ERBB4 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.) Background:This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with mµLtiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregµLins and other factors and induces a variety of cellµLar responses including mitogenesis and differentiation. MµLtiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellµLar fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fµLly characterized. Immunogen:v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) Synonyms:HER4 Observed MW:180 kDa Uniprot ID:Q15303 Reactivity:Mouse, Rat Tested Application:ELISA, IHC, WB Recommended dilution:WB: 1:500 - 1:1000; IHC: 1:50 - 1:100 Gene ID:2066 Research Area:Signal Transduction, Metabolism, CardiovascµLar, Immunology, Cancer, Developmental biology