ELISA HER2|ErbB2 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor(EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas. This antibody raised against a syntheQuantityd peptide corresponding to 1237-1255aa of HER2 recognizes the 185-kDa fµLl-length glycosylated form and other lower molecµLar-mass forms of HER2, including the truncated form. Immunogen:v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog(avian) Synonyms:CD340, ERBB2, HER 2, HER 2/neu, HER2, mLN 19, mLN19, NEU, NGL, p185, p185erbB2, Proto oncogene c ErbB 2, Proto oncogene Neu, TKR1 Observed MW:185 kDa Uniprot ID:P04626 Reactivity:, Mouse Tested Application:ELISA, WB, IHC, FC, IP Recommended dilution:WB: 1:1000-1:10000; IP: 1:200-1:2000; IHC: 1:50-1:200 Gene ID:2064 Research Area:Signal Transduction, Metabolism, CardiovascµLar, Immunology, Cancer, Developmental biology, Stem Cells