ELISA HERC5 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Major E3 ligase for ISG15 conjµgation. Acts as a positive regµLator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which resµLts in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virµLence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which resµLts in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly syntheQuantityd proteins in a cotranslational manner. In an interferon-stimµLated cell, newly translated viral proteins are primary targets of ISG15. Immunogen:hect domain and RLD 5 Synonyms:CEB1, CEBP1 Observed MW:128 kDa Uniprot ID:Q9UII4 Reactivity: Tested Application:ELISA, WB Recommended dilution:WB: 1:500-1:2000 Gene ID:51191 Research Area:Immunology, Metabolism