ELISA HEXA anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.) Background:This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecµLes containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumµLation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing resµLts in mµLtiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Immunogen:hexosaminidase A (alpha polypeptide) Synonyms:HEXA, Hexosaminidase subunit A, TSD Observed MW:60 kDa Uniprot ID:P06865 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 Gene ID:3073 Research Area:Neuroscience, Metabolism